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Email: forough.ghasemi20@gmail.com
Fax: +98-26-32701067
P.O. Box: 3135933151, Karaj-Iran
ORCiD: 0000-0003-1093-2058
Welcome to the Ghasemi Research Group!
Where Chemistry and Plasmonic/Luminescent Nanoparticles Meet to Design Colorimetric/Fluorometric Sensors for Environmental, Agricultural, and Medicinal Applications …
Education
Sharif University of Technology, Tehran-Iran, 2017-2018
Thesis: “Design of ratiometric fluorescent nanoprobes for naked-eye detection”
Tehran University of Medical Sciences, Tehran-Iran, 2016-2017
Thesis: “Design and fabrication of nanostructured substrates for the detection of biomolecules”
Bionanoplasmonics laboratory, Professor Luis M. Liz-Marzan, CIC biomaGUNE, Spain, 2016
Thesis: “Recognition of biologically relevant glycans by surface-enhanced Raman spectroscopy”
Sharif University of Technology, Tehran-Iran, 2012-2016
Thesis: “Colorimetric sensor array design for classification and detection of nanoparticles and biomolecules”
Sharif University of Technology, Tehran-Iran, 2010-2012
Thesis: “Determination of protein absorption profile at the surface of biocompatible superparamagnetic iron oxide nanoparticles using gel electrophoresis”
University of Kharazmi, Karaj-Iran, 2006-2010
Honor, Awards, and Scholarships
Research Interest
Research Area
The surface plasmon resonance (SPR) of plasmonic nanoparticles arises from the interaction between incident light and free electrons in the NPs' conduction band, which drives free electrons to oscillate collectively. SPR depends on the physicochemical properties of plasmonic nanoparticles including size, shape, composition, surface coating, and electrical charge of nanoparticles. These physicochemical properties determine the potential application of plasmonic nanoparticles in different fields (Green Plasmonic Nanoparticles, In Encyclopedia of Green Materials, Springer, 2022).
Plasmonic Nanosensors
Colorimetric sensors rely on changes in the optical properties of nanoparticles due to their aggregation, formation, enzyme-like activity, etching, anti-aggregation, and growth. As a result of these mechanisms, a redshift/blueshift/increase/decrease occurs in the SPR band of nanoparticles and consequently visible color change of the sensor (Analytica Chimica Acta, 1238, 2023, 340640).
Nanoparticle-Based Optical Sensor Arrays
Critical decisions on the treatment of diseases, food/drug quality control, pollution issues, criminal investigations, explosive detections, and many other medical, environmental, industrial, and security concerns require the development of effective assays, capable of simultaneous determination of various analytes of interest. Moving from specific individual lock-and-key sensors toward cross-reactive sensor arrays enables the recognition and discrimination of groups of target species. The presence of cross-reactive sensing elements not only leads to increase in the number of detectable analytes, but also allows make use of non-specific interactions for recognition. This so-called “differential sensing” has been inspired by nature’s use of arrays of receptors in the senses of taste and smell. Each receptor (sensing element) has a semi-selective response to a particular analyte and the specificity of the sensor is accomplished by pattern-based recognition in which distinct response patterns are attained for each analyte. Developing a sensor array seems like employing a detective whom gathers clues from several evidences to reveal the truth (Nanoscale, 9, 2017, 16546).
Nanoscale, 9, 2017, 16546.
Ratiometric Fluorescent Nanoprobes
Signal generation mechanisms for naked-eye detection of analytes are becoming increasingly popular in various sensing fields. These approaches are mainly advantageous when instrumentation is not available, such as for on-site assays, point-of-care tests, and healthcare diagnostics in resource-constrained areas. Among various naked eye detection approaches currently being explored for non-invasive quantitative measurements, ratiometric fluorescence sensing has received particular attention as a potential technique to overcome the limitations of intensity-based probes. This technique relies on changes in the intensity of two or more emission bands (induced by the analyte), resulting in an effective internal referencing which improves the sensitivity. Taking advantage of this self-calibration, together with the unique optophysical properties of nanoparticles (NPs), in ratiometric fluorescent nanoprobes, high sensitivity and reliability can be obtained, allowing precise naked-eye detection of the analytes. Over the past few years, a vast number of ratiometric sensing probes using nanostructured fluorophores have been designed and reported for a wide variety of sensing, imaging, and biomedical applications (Analytica Chimica Acta, 1079, 2019, 30-58).
Analytica Chimica Acta, 1079, 2019, 30-58.
Publications
Patents
Books/Book Chapters
https://www.sciencedirect.com/science/article/pii/B9780323994545000081?via%3Dihub
https://link.springer.com/referenceworkentry/10.1007/978-981-16-4921-9_23-1
https://www.sciencedirect.com/science/article/pii/B9780323902441000033
https://link.springer.com/referenceworkentry/10.1007/978-981-16-4921-9_41-1
Review Articles
https://journalofbiosafety.ir/article-1-512-en.html
https://www.sciencedirect.com/science/article/abs/pii/S0003267022012119?via%3Dihub
https://www.sciencedirect.com/science/article/abs/pii/S0278691521000594
https://pubs.rsc.org/en/Content/ArticleLanding/2020/AN/D0AN01211D#!divAbstract
https://www.sciencedirect.com/science/article/pii/S0003267019307603#!
https://pubs.rsc.org/en/content/articlelanding/2017/nr/c7nr03311g/unauth#!divAbstract
Research Papers
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202400080
https://pubs.acs.org/doi/10.1021/acsanm.3c04982
https://www.sciencedirect.com/science/article/abs/pii/S003991402300872X
https://ijswr.ut.ac.ir/article_93583.html?lang=en
https://pubs.acs.org/doi/10.1021/acs.analchem.3c01904
https://www.sciencedirect.com/science/article/abs/pii/S0003267022011515
https://www.sciencedirect.com/science/article/abs/pii/S0925400522001216
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202103094
https://iopscience.iop.org/article/10.1088/1361-6528/ac3704
https://pubs.rsc.org/en/content/articlelanding/2021/ay/d1ay01117k
https://pubs.acs.org/doi/10.1021/acsami.1c03183?goto=supporting-info
https://www.sciencedirect.com/science/article/abs/pii/S0278691521001423
https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay02039g#!divAbstract
https://pubs.rsc.org/en/content/articlelanding/2020/nr/c9nr08784b#!divAbstract
https://www.sciencedirect.com/science/article/abs/pii/S138614251931193X#!
https://www.sciencedirect.com/science/article/pii/S0026265X19304382?via%3Dihub
https://www.sciencedirect.com/science/article/pii/S0039914019304011
https://pubs.acs.org/doi/10.1021/acschemneuro.8b00622
https://www.sciencedirect.com/science/article/pii/S0003267018309073
https://www.nature.com/articles/s41598-018-32416-z
https://www.nature.com/articles/s41598-018-30915-7
https://www.sciencedirect.com/science/article/pii/S0925400518309675
https://pubs.rsc.org/en/content/articlelanding/2018/nr/c8nr00195b/unauth#!divAbstract
https://www.sciencedirect.com/science/article/pii/S0925400517324747
http://www.nsmsi.ir/article_28246_en.html
https://www.nature.com/articles/s41598-017-08704-5
https://ieeexplore.ieee.org/document/7997733
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160206
https://www.nature.com/articles/s41598-017-00983-2
https://www.sciencedirect.com/science/article/pii/S0003267016302744
https://www.sciencedirect.com/science/article/pii/S0003267015004766
https://pubs.rsc.org/en/content/articlelanding/2015/nr/c4nr00580e/unauth#!divAbstract
Conferences